Cirrhosis of Portal Hypertension
Splanchnic arterial vasodilation
Decrease in circulating arterial blood volume
Activation of rennin-angiotensin and sympathetic nervous systems and antidiuretic hormone
Kidney retains sodium and water
Hypervolemia
(Increased fluid volume)
Decreased synthesis of albumin moves fluid form the vascular system into the peritoneal space
Persistent activation of systems for retention of sodium and water
ascites and edema formation
Continued arterial underfilling; cycle repeats
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